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Article

Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer's disease.

Journal of neurochemistry - 1 Nov 2007

Maloney Bryan, Ge Yuan-Wen, Alley George M, Lahiri Debomoy K

Abstract excerpt

Apolipoprotein E (ApoE), encoded by the apolipoprotein E gene (APOE), plays an important role in the pathogenesis of Alzheimer's disease (AD). The APOE epsilon4 variant is strongly associated with AD. APOE promoter polymorphisms have also been reported to associate with higher AD risk. Mouse mode...

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Source

Identifiers

PMID: 17854398
DOI: 10.1111/j.1471-4159.2007.04831.x

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17854398-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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