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Article

Cancer stem cells in gliomas: Identifying and understanding the apex cell in cancer's hierarchy

5 May 2011

Abstract excerpt

Neuro-oncology research has rediscovered a complexity of nervous system cancers through the incorporation of cellular heterogeneity into tumor models with cellular subsets displaying stem-cell characteristics. Self-renewing cancer stem cells (CSCs) can propagate tumors and yield nontumorigenic tumor bulk cells that display a more differentiated phenotype. The ability to prospectively isolate and interrogate CSCs...

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PMID: 21547954
DOI: 10.1002/glia.21185

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