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Article

Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer.

International journal of cancer - 15 Apr 2012

Sunaga Noriaki, Imai Hisao, Shimizu Kimihiro, Shames David S, Kakegawa Seiichi, Girard Luc, Sato Mitsuo, Kaira Kyoichi, Ishizuka Tamotsu, Gazdar Adi F, Minna John D, Mori Masatomo

Abstract excerpt

The CXC chemokine interleukin-8 (IL-8) is an angiogenic growth factor that is overexpressed in various cancers, including non-small cell lung cancer (NSCLC). Previously, IL-8 was shown as a transcriptional target of RAS signaling, raising the possibility of its role in oncogenic KRAS-driven NSCLC. Using microarray analysis, we identified IL-8 as the most downregulated gene by shRNA-mediated KRAS knockdown in...

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Identifiers

PMID: 21544811
DOI: 10.1002/ijc.26164
PMCID: PMC3374723

Genes

KRAS
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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