Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway.

Scientific reports - 4 Sept 2015

Tsai Meng-Feng, Chang Tzu-Hua, Wu Shang-Gin, Yang Hsiao-Yin, Hsu Yi-Chiung, Yang Pan-Chyr, Shih Jin-Yuan

Abstract excerpt

Malignant pleural effusion (MPE) is a common clinical problem in non-small cell lung carcinoma (NSCLC) patients; however, the underlying mechanisms are still largely unknown. Recent studies indicate that the frequency of the L858R mutant form of the epidermal growth factor receptor (EGFR-L858R) is higher in lung adenocarcinoma with MPE than in surgically resected specimens, suggesting that lung adenocarcinoma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CXCL12

Share to ErbB Receptors

Share to Lung Neoplasms

Share to Neoplasm Invasiveness

Share to Pleural Effusion, Malignant

Share to Receptors, CXCR4

Source

Open in PubMed Open full text

Identifiers

PMID: 26338423
DOI: 10.1038/srep13574
PMCID: PMC4559673

Genes

EGFR
CXCR4
CXCL12

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway.PMID 26338423Read ↗

[Mechanism of EGFR Over-expression and Mutations Leading to Biological Characteristics Changes of Human Lung Adenocarcinoma Cells through CXCR4/CXCL12 Signaling Pathway].Semantic proximity Read ↗

Survival of lung adenocarcinoma patients with malignant pleural effusion.Semantic proximity Read ↗

Overexpression of CD44 is associated with the occurrence and migration of non-small cell lung cancerSemantic proximity Read ↗

Concomitant overexpression of EGFR and CXCR4 is associated with worse prognosis in a new molecular subtype of non-small cell lung cancerSemantic proximity Read ↗

Relationship between EGFR gene mutation and local metastasis of resectable lung adenocarcinoma.Semantic proximity Read ↗

Frequent epidermal growth factor receptor gene mutations in malignant pleural effusion of lung adenocarcinoma.Semantic proximity Read ↗

High expression of E-cadherin in pleural effusion cells predicts better prognosis in lung adenocarcinoma patients.Semantic proximity Read ↗

Frequency of EGFR mutations in lung adenocarcinoma with malignant pleural effusion: Implication of cancer biological behaviour regulated by EGFR mutation.Semantic proximity Read ↗

Clinical impact of pleural fluid carcinoembryonic antigen on therapeutic strategy and efficacy in lung adenocarcinoma patients with malignant pleural effusion.Semantic proximity Read ↗

CXCR4: From Signaling to Clinical Applications in Neuroendocrine NeoplasmsSemantic proximity Read ↗

CXCR4 is involved in CD133-induced EMT in non-small cell lung cancer.Semantic proximity Read ↗

Development of Pericardial Effusion in Non-small Cell Lung Cancer Is Associated with the Presence of EGFR/ALK Mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.