Article
Simple pharmacokinetic models accounting for drug monitoring results of atomoxetine and its 4-hydroxylated metabolites in Japanese pediatric patients genotyped for cytochrome P450 2D6.
Drug metabolism and pharmacokinetics - 1 Apr 2020
Notsu Yuki, Shimizu Makiko, Sasaki Tatsuro, Nakano Ayane, Ota Miki, Yoshida Sayaka, Yamazaki Hiroshi
Abstract excerpt
Atomoxetine is an approved medicine for attention-deficit/hyperactivity disorder and a cytochrome P450 2D6 (CYP2D6) probe substrate. Simple physiologically based pharmacokinetic (PBPK) models and compartment models were set up to account for drug monitoring results of 33 Japanese patients (6-15 years of age) to help establish the correct dosage for the evaluation of clinical outcomes. The steady-state one-point...
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