Article
Mammalian target of rapamycin pathway activation is associated to RET mutation status in medullary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism - 1 Jul 2011
Rapa Ida, Saggiorato Enrico, Giachino Daniela, Palestini Nicola, Orlandi Fabio, Papotti Mauro, Volante Marco
Abstract excerpt
CONTEXT: The genetic pathways involved in medullary thyroid carcinomas (MTC), except for RET mutations, are largely unknown, as is the detailed mapping of proteins activated as a consequence of RET tyrosine kinase phosphorylation. OBJECTIVE: The present study was designed to screen for the presence of mutations in other genes downstream to RET activation and to detect the activation patterns of a panel of...
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