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Article

Medullary Thyroid Cancer: Molecular Biology and Novel Molecular Therapies

1 Jan 2009

Abstract excerpt

Medullary thyroid cancer (MTC) arises from neural-crest-derived parafollicular C cells of the thyroid gland and accounts for approximately 4% of all thyroid cancers. Up to 25-30% of MTC cases occur as inherited disorders while the remaining cases represent the sporadic form of the disease. In this review, the structure and signalling properties of the RET proto-oncogene in its wild-type and mutant forms, and its...

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PMID: 19468197
DOI: 10.1159/000220827

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