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Article

Recent advances in the molecular pathogenesis and targeted therapies of medullary thyroid carcinoma.

Current opinion in oncology - 1 May 2012

Almeida Madson Q, Hoff Ana O

Abstract excerpt

PURPOSE OF REVIEW: This review will focus on the recent advances in molecular pathogenesis and targeted therapies for medullary thyroid carcinoma (MTC). Unlike hereditary MTC in which rearranged during transfection (RET) mutations are the most important precipitating events, in sporadic MTC the genetic or molecular biomarkers are yet to be established. RECENT FINDINGS: Targeted molecular therapies that inhibit...

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Piperidines
Antineoplastic Agents
Carcinoma, Neuroendocrine
Clinical Trials, Phase III as Topic
Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thyroid Neoplasms

TOR Serine-Threonine Kinases

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Identifiers

PMID: 22343387
DOI: 10.1097/CCO.0b013e328351c71a

Genes

RET
EGFR
MET

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