Article
Chasing the ubiquitous RET proto-oncogene in South African MEN2 families--implications for the surgeon.
South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie - 1 Nov 2010
Moore S W, Zaahl M G
Abstract excerpt
UNLABELLED: The RET proto-oncogene (REarranged during Transfection; RET) plays an important role in the causation of many thyroid tumours. Germline RET proto-oncogene missense mutations have been clearly linked to medullary thyroid carcinoma (MTC) and the inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN2A, MEN2B). METHODS: We investigated a cohort of MEN2-related patients referred to Tygerberg...
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