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Article

Prophylactic thyroidectomy in multiple endocrine neoplasia: the impact of molecular mechanisms of RET proto-oncogene.

Langenbeck's archives of surgery - 1 Mar 2003

Frilling Andrea, Weber Frank, Tecklenborg Carsten, Broelsch Christoph Erich

Abstract excerpt

BACKGROUND: Multiple endocrine neoplasia (MEN) type 2, a cancer syndrome inherited in the dominant fashion, is defined by the occurrence of medullary thyroid carcinoma (MTC), either as a singular lesion (familial medullary thyroid carcinoma, FMTC) or with the variable expression of pheochromocytoma, hyperparathyroidism (MEN 2A), ganglioneuromas, buccal neuromas and Marfanoid-like phenotype (MEN 2B). DISCUSSION:...

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Source

Identifiers

PMID: 12690476
DOI: 10.1007/s00423-003-0368-4

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Very early detection of <i>RET</i> proto‐oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 childrenSemantic proximity Read ↗

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