Article
Very early detection of <i>RET</i> proto‐oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children
15 Jan 2002
Abstract excerpt
BACKGROUND: Multiple endocrine neoplasia type 2 (MEN 2) is an inherited disease caused by germline mutations in the RET proto-oncogene, and is responsible for the development of endocrine neoplasia. Its prognosis is dependent on the appearance and spread of medullary thyroid carcinoma (MTC). Relatives at risk can be identified before clinical or biochemical signs of the disease become evident. METHODS: Twenty-one...
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