Evidence for a link between TNFRSF11A and risk of breast cancer.

doi:10.1007/s10549-011-1546-7

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Article

Evidence for a link between TNFRSF11A and risk of breast cancer.

Breast cancer research and treatment - 1 Oct 2011

Bonifaci Núria, Palafox Marta, Pellegrini Pasquale, Osorio Ana, Benítez Javier, Peterlongo Paolo, Manoukian Siranoush, Peissel Bernard, Zaffaroni Daniela, Roversi Gaia, Barile Monica, Viel Alessandra, Mariette Frederique, Bernard Loris, Radice Paolo, Kaufman Bella, Laitman Yael, Milgrom Roni, Friedman Eitan, Sáez María E, Climent Fina, Soler María Teresa, Diez Orland, Balmaña Judith, Lasa Adriana, Ramón y Cajal Teresa, Miramar María-Dolores, de la Hoya Miguel, Pérez-Segura Pedro, Caldés Trinidad, Moreno Víctor, Urruticoechea Ander, Brunet Joan, Lázaro Conxi, Blanco Ignacio, Pujana Miguel Angel, González-Suárez Eva

Abstract excerpt

Intracellular signaling mediated by the receptor activator of nuclear factor-κB [Rank, encoded by the tumor necrosis factor receptor superfamily, member 11a (Tnfrsf11a) gene] is fundamental for mammary gland development in mice, regulating the expansion of stem and progenitor cell compartments. Conversely, Rank overexpression in mice promotes abnormal proliferation and impairs differentiation, leading to an...

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PMID: 21541702
DOI: 10.1007/s10549-011-1546-7

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Related research

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Evidence for a link between TNFRSF11A and risk of breast cancer.PMID 21541702Read ↗

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Genetic variation in the TNFRSF11A gene encoding RANK is associated with susceptibility to Paget's disease of bone.Semantic proximity Read ↗

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