Article
Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer.
Neoplasia (New York, N.Y.) - 1 Feb 2021
He Ling, Bhat Kruttika, Duhacheck-Muggy Sara, Ioannidis Angeliki, Zhang Le, Nguyen Nhan T, Moatamed Neda A, Pajonk Frank
Abstract excerpt
Pro-inflammatory conditions have long been associated with mammary carcinogenesis and breast cancer progression. The underlying mechanisms are incompletely understood but signaling of pro-inflammatory cytokine TNFα through its receptors TNFR1 and TNFR2 is a major mediator of inflammation in both obesity and in the response of tissues to radiation, 2 known risk factors for the development of breast cancer. Here,...
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