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Article

Multiple pathways counteract cell death induced by RB1 loss: implications for cancer.

Cell cycle (Georgetown, Tex.) - 15 May 2011

Ciavarra Giovanni, Zacksenhaus Eldad

Abstract excerpt

Inactivation of the tumor suppressor RB1 leads to cell proliferation, cell death and abortive differentiation in certain tissues and physiological contexts. Anti-apoptotic signals are thought to be the most important mechanism by which RB1-mutant cells escape cell death. Indeed, in the course of neoplastic transformation RB1 is often inactivated in conjunction with a mutation in the pro-apoptotic tumor suppressor...

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PMID: 21540641
DOI: 10.4161/cc.10.10.15520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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