Article

Low expression of ANT1 confers oncogenic properties to rhabdomyosarcoma tumor cells via modulating metabolism and death pathways

2020-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Rhabdomyosarcoma (RMS) is the most frequent form of pediatric soft-tissue sarcoma. It is divided into 2 main subtypes: ERMS (embryonal) and ARMS (alveolar). Current treatments are based on chemotherapy, surgery and radiotherapy. 5-year survival rate remains of 70% since 2000, despite several clinical trials. RMS cells are thought to derive from muscle lineage precursors. During development, myog...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76148acf-4862-5d36-ac03-a34a24ebd321
DOI: 10.1101/2020.03.03.973719

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low expression of ANT1 confers oncogenic properties to rhabdomyosarcoma tumor cells via modulating metabolism and death pathwaysDOI 10.1101/2020.03.03.973719Read

Low expression of ANT1 confers oncogenic properties to rhabdomyosarcoma tumor cells by modulating metabolism and death pathwaysSemantic proximity Read

High-level dynein impairs mitochondrial distribution and differentiation of rhabdomyosarcoma cellsSemantic proximity Read

Defining the gene expression signature of rhabdomyosarcoma by meta-analysisSemantic proximity Read

Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcomaSemantic proximity Read

Genetics, epigenetics and redox homeostasis in rhabdomyosarcoma: Emerging targets and therapeuticsSemantic proximity Read

Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevanceSemantic proximity Read

SMARCB1 Deficiency as a Driver of the Hallmarks of Cancer in Rhabdoid Tumours: Novel Insights into Dysregulated Energy Metabolism, Emerging Targets, and Ongoing Clinical TrialsSemantic proximity Read

Probing for a deeper understanding of rhabdomyosarcoma: insights from complementary model systems.Semantic proximity Read

Single-cell mapping of tumor heterogeneity in pediatric rhabdomyosarcoma reveals developmental signatures with therapeutic relevanceSemantic proximity Read

Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcomaSemantic proximity Read

Childhood RhabdomyosarcomaSemantic proximity Read

PROX1 transcription factor controls rhabdomyosarcoma growth, stemness, myogenic properties and therapeutic targetsSemantic proximity Read