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Article

Lack of a relationship between the polymorphism of debrisoquine oxidation and lung cancer.

British journal of clinical pharmacology - 1 May 1991

Duche J C, Joanne C, Barre J, de Cremoux H, Dalphin J C, Depierre A, Brochard P, Tillement J P, Bechtel P

Abstract excerpt

1. Determination of debrisoquine oxidation phenotype was carried out in 119 healthy subjects, 135 patients with chronic bronchitis and 153 patients with lung cancer, all of Caucasian origin. 2. A non-Gaussian distribution of the log D/HD ratio was observed in the three groups. 3. Assuming an antimode of 1.12, the proportion of PMs was found to be 6.7% in healthy subjects, 8.9% in chronic bronchitics and 6.5% in...

Topics

Adult
Aged
Aged, 80 and over
Bronchitis
Chronic Disease
Debrisoquin
Female
Humans
Lung Neoplasms
Male
Middle Aged
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 1888620
DOI: 10.1111/j.1365-2125.1991.tb05575.x
PMCID: PMC1368471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1888620-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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