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Article

Data integration workflow for search of disease driving genes and genetic variants.

PloS one - 12 Apr 2011

Karinen Sirkku, Heikkinen Tuomas, Nevanlinna Heli, Hautaniemi Sampsa

Abstract excerpt

Comprehensive characterization of a gene's impact on phenotypes requires knowledge of the context of the gene. To address this issue we introduce a systematic data integration method Candidate Genes and SNPs (CANGES) that links SNP and linkage disequilibrium data to pathway- and protein-protein interaction information. It can be used as a knowledge discovery tool for the search of disease associated causative...

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PMID: 21533266
DOI: 10.1371/journal.pone.0018636
PMCID: PMC3075259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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