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Article

Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development.

Journal of the Association for Research in Otolaryngology : JARO - 1 Jun 2006

Pawlowski Karen S, Kikkawa Yayoi S, Wright Charles G, Alagramam Kumar N

Abstract excerpt

The Ames waltzer (av) mouse mutant exhibits auditory and vestibular abnormalities resulting from mutation of protocadherin 15 (Pcdh15). Ames waltzer has been identified as an animal model for inner ear pathology associated with Usher syndrome type 1F. Studies correlating anatomical phenotype with severity of genetic defect in various av alleles are providing better understanding of the role played by Pcdh15 in...

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Cadherin Related Proteins
Cadherins
Ear, Inner
Hair Cells, Auditory
Mice, Mutant Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Electron, Scanning

Microscopy, Electron, Transmission

Protein Precursors

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Identifiers

PMID: 16408167
DOI: 10.1007/s10162-005-0024-5
PMCID: PMC2504581

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Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development.PMID 16408167Read ↗

Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts.Semantic proximity Read ↗

A new spontaneous mutation in the mouse Ames waltzer gene, Pcdh15.Semantic proximity Read ↗

A new spontaneous mutation in the mouse protocadherin 15 gene.Semantic proximity Read ↗

The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene.Semantic proximity Read ↗

Characterization of a new allele of Ames waltzer generated by ENU mutagenesis.Semantic proximity Read ↗

Characterization of vestibular dysfunction in the mouse model for Usher syndrome 1F.Semantic proximity Read ↗

Expression of Pcdh15 in the inner ear, nervous system and various epithelia of the developing embryo.Semantic proximity Read ↗

The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.Semantic proximity Read ↗

Assessment of retinal structure and function in Ames waltzer mice.Semantic proximity Read ↗

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.Semantic proximity Read ↗

Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans.Semantic proximity Read ↗

Neuroepithelial defects of the inner ear in a new allele of the mouse mutation Ames waltzer.Semantic proximity Read ↗

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