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Article

Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts.

Investigative ophthalmology & visual science - 1 Jul 2006

Haywood-Watson Ricky J L, Ahmed Zubair M, Kjellstrom Sten, Bush Ronald A, Takada Yuichiro, Hampton Lori L, Battey James F, Sieving Paul A, Friedman Thomas B

Abstract excerpt

PURPOSE: Mutations of PCDH15, the gene encoding protocadherin 15, cause either nonsyndromic deafness DFNB23 or Usher syndrome type 1F (USH1F) in humans and deafness with balance problems in Ames waltzer (av) mice. Persons with USH1 usually begin to exhibit signs of retinitis pigmentosa (RP) in ea...

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Source

Identifiers

PMID: 16799054
DOI: 10.1167/iovs.06-0108

Genes

ERG
PCDH15
ABR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16799054-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts.PMID 16799054Read ↗

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PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23.Semantic proximity Read ↗

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