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Article

The calcium-sensing receptor is necessary for the rapid development of hypercalcemia in human lung squamous cell carcinoma.

Neoplasia (New York, N.Y.) - 1 May 2011

Lorch Gwendolen, Viatchenko-Karpinski Serge, Ho Hsiang-Ting, Dirksen Wessel P, Toribio Ramiro E, Foley John, Györke Sandor, Rosol Thomas J

Abstract excerpt

The calcium-sensing receptor (CaR) is responsible for the regulation of extracellular calcium (Ca(2+) (o)) homeostasis. CaR activation has been shown to increase proliferation in several cancer cell lines; however, its presence or function has never been documented in lung cancer. We report that Ca(2+) (o)-activated CaR results in MAPK-mediated stimulation of parathyroid hormone-related protein (PTHrP) production...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitogen-Activated Protein Kinases

Share to Parathyroid Hormone-Related Protein

Share to Receptors, Calcium-Sensing

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Source

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Identifiers

PMID: 21532883
DOI: 10.1593/neo.101620
PMCID: PMC3084619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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