Article
Comprehensive analysis of epidermal growth factor receptor gene status in lung adenocarcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2011
Li Chenguang, Sun Yihua, Fang Zhaoyuan, Han Xiangkun, Fang Rong, Zhang Yang, Pan Yunjian, Zhang Wenjing, Ren Yan, Ji Hongbin, Chen Haiquan
Abstract excerpt
INTRODUCTION: The epidermal growth factor receptor (EGFR) gene status including tyrosine kinase domain somatic mutations, increased copy number, and protein overexpression are reported to be associated with response to EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer. The purpose of this study was to elucidate the prevalence of activated EGFR gene and the association between mutation,...
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