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Article

Genomic profiles specific to patient ethnicity in lung adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2011

Broët Philippe, Dalmasso Cyril, Tan Eng Huat, Alifano Marco, Zhang Shenli, Wu Jeanie, Lee Ming Hui, Régnard Jean-François, Lim Darren, Koong Heng Nung, Agasthian Thirugnanam, Miller Lance D, Lim Elaine, Camilleri-Broët Sophie, Tan Patrick

Abstract excerpt

PURPOSE: East-Asian (EA) patients with non-small-cell lung cancer (NSCLC) are associated with a high proportion of nonsmoking women, epidermal growth factor receptor (EGFR)-activating somatic mutations, and clinical responses to tyrosine kinase inhibitors. We sought to identify novel molecular differences between NSCLCs from EA and Western European (WE) patients. EXPERIMENTAL DESIGN: A total of 226 lung...

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PMID: 21521776
DOI: 10.1158/1078-0432.CCR-10-2185

Genes

EGFR
KRAS

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