Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification.

doi:10.1128/JVI.64.6.2819-2824.1990

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Article

Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification.

Journal of virology - 1 Jun 1990

Summers J, Smith P M, Horwich A L

Abstract excerpt

Primary duck hepatocytes were infected with a mutant duck hepatitis B virus defective in envelope protein but competent for viral DNA synthesis. Cells infected by this mutant accumulated higher levels of viral covalently closed, circular DNA (cccDNA) than those infected by wild-type virus. The ac...

Topics

Animals
Cell Line
Cells, Cultured
DNA, Circular
DNA, Viral
Ducks
Gene Amplification
Gene Expression Regulation, Viral
Genes, Viral
Hepadnaviridae
Liver
Mutation
Plasmids
Transfection
Viral Envelope Proteins

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