Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective replication units of hepatitis B virus.

Journal of virology - 1 Apr 1990

Schranz P, Zentgraf H, Loncarević I F, Niepmann M, Schröder C H

Abstract excerpt

Templates for the synthesis of defective hepatitis B virus RNA pregenomes were constructed. Viral sequences in these constructs were replaced by the neomycin resistance gene. Deletions spanned up to 80% of the genome and did not include the cohesive end region. The size of the defective replication units was reduced up to half of the wild-type unit length. After cotransfection with replication competent wild-type...

Topics

Carcinoma, Hepatocellular
DNA Replication
DNA, Viral
Enhancer Elements, Genetic
Hepatitis B virus
Humans
Liver Neoplasms
Mutation
Plasmids
RNA, Viral
Templates, Genetic
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 2157068
DOI: 10.1128/JVI.64.4.1851-1854.1990
PMCID: PMC249328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2157068-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective replication units of hepatitis B virus.PMID 2157068Read ↗

Genetic Analysis of Hepatitis C Virus with Defective Genome and Its Infectivity in VitroSemantic proximity Read ↗

Synthesis of hepadnavirus particles that contain replication-defective duck hepatitis B virus genomes in cultured HuH7 cells.Semantic proximity Read ↗

Hepatitis B Virus DNA Integration: In Vitro Models for Investigating Viral Pathogenesis and PersistenceSemantic proximity Read ↗

Replication of DHBV genomes with mutations at the sites of initiation of minus- and plus-strand DNA synthesis.Semantic proximity Read ↗

A bulged region of the hepatitis B virus RNA encapsidation signal contains the replication origin for discontinuous first-strand DNA synthesisSemantic proximity Read ↗

Repair and polyadenylation of a naturally occurring hepatitis C virus 3' nontranslated region-shorter variant in selectable replicon cell lines.Semantic proximity Read ↗

Pregenomic RNA Launch Hepatitis B Virus Replication System Facilitates the Mechanistic Study of Antiviral Agents and Drug-Resistant Variants on Covalently Closed Circular DNA SynthesisSemantic proximity Read ↗

Infection of ducklings with virus particles containing linear double-stranded duck hepatitis B virus DNA: illegitimate replication and reversion.Semantic proximity Read ↗

Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytesSemantic proximity Read ↗

A double-spliced defective hepatitis B virus genome derived from hepatocellular carcinoma tissue enhanced replication of full-length virus.Semantic proximity Read ↗

Restoration in vivo of defective hepatitis delta virus RNA genomes.Semantic proximity Read ↗

Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.