Replication-defective missense mutations within the terminal protein and spacer/intron regions of the polymerase gene of human hepatitis B virus.

doi:10.1016/0042-6822(91)91007-4

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Article

Replication-defective missense mutations within the terminal protein and spacer/intron regions of the polymerase gene of human hepatitis B virus.

Virology - 1 Aug 1991

Faruqi A F, Roychoudhury S, Greenberg R, Israel J, Shih C H

Abstract excerpt

We have analyzed 11 independent mutations located at various domains of the polymerase gene (pol) of human hepatitis B virus. Surprisingly, one of the two missense mutants within the spacer/intron region appears to be lethal. This result further defines the N-terminal limit of the reverse transcr...

Topics

Blotting, Northern
Blotting, Southern
Cell Line
DNA, Ribosomal
DNA, Viral
Genes, pol
Hepatitis B virus
Humans
Introns
Mutation
Transcription, Genetic
Virus Replication

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