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Article

Molecular characterization of the interaction between sialylated Neisseria gonorrhoeae and factor H.

The Journal of biological chemistry - 24 Jun 2011

Shaughnessy Jutamas, Ram Sanjay, Bhattacharjee Arnab, Pedrosa Joana, Tran Connie, Horvath Gabor, Monks Brian, Visintin Alberto, Jokiranta T Sakari, Rice Peter A

Abstract excerpt

Human factor H (HufH), a key inhibitor of the alternative pathway of complement, binds to Neisseria gonorrhoeae and constitutes an important mechanism of human-specific complement evasion. The C-terminal domain 20 of HufH contains the binding site for sialylated gonococci. We exploited differences in amino acid sequences between human and non-binding chimpanzee fH domain 20 to create cross-species mutations to...

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Identifiers

PMID: 21531728
DOI: 10.1074/jbc.M111.225516
PMCID: PMC3121369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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