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The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis

1 Sept 1999

Abstract excerpt

Neisseria gonorrhoeae and Neisseria meningitidis have evolved intricate mechanisms to evade complement-mediated killing. Sialylation of gonococcal lipooligosaccharide (LOS) results in conversion of previously serum sensitive strains to unstable serum resistance, which is mediated by factor H binding. Porin (Por) is also instrumental in mediating stable serum resistance in gonococci. The 5th loop of certain...

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PMID: 10698346
DOI: 10.1016/s0161-5890(99)00114-5

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