Article
Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase.
The Journal of biological chemistry - 14 Nov 2014
Neau David B, Bender Gunes, Boeglin William E, Bartlett Sue G, Brash Alan R, Newcomer Marcia E
Abstract excerpt
Lipoxygenases (LOX) play critical roles in mammalian biology in the generation of potent lipid mediators of the inflammatory response; consequently, they are targets for the development of isoform-specific inhibitors. The regio- and stereo-specificity of the oxygenation of polyunsaturated fatty acids by the enzymes is understood in terms of the chemistry, but structural observation of the enzyme-substrate...
Topics
- Animals
- Arachidonate Lipoxygenases
- Arachidonic Acid
- Binding Sites
- Catalysis
- Crystallography, X-Ray
- Humans
- Inflammation
- Iron
- Lipids
- Models, Molecular