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Mitochondrial/lysosomal toxic cross-talk plays a key role in cisplatin nephrotoxicity

1 Sept 2010

Abstract excerpt

Cisplatin is widely used chemotherapeutic agent for the treatment of several human malignancies. Dose-related nephrotoxicity is the major adverse effect of cisplatin. The cellular and molecular mechanisms behind the cisplatin nephrotoxicity have not yet been completely understood. In this study, cytotoxic effect of cisplatin on renal proximal tubular (RPT) cells was evaluated. Our results showed that cytotoxic...

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PMID: 20809784
DOI: 10.3109/00498254.2010.512093

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