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Cell proliferation, apoptosis and mitochondrial damage in rat B50 neuronal cells after cisplatin treatment

7 Apr 2008

Abstract excerpt

OBJECTIVES: Cisplatin (cisPt) is used as a chemotherapeutic agent for the treatment of a variety of human tumours; more recently, it has been demonstrated that tumour cell exposure to cisPt ultimately results in apoptosis, but the mechanism by which nuclear cisPt/DNA generates the cytoplasmic cascade of events involved has not been clarified. We have investigated the effects of cisPt on proliferation in the...

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PMID: 18397337
DOI: 10.1111/j.1365-2184.2008.00530.x

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