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Article

MMSET Is Highly Expressed and Associated with Aggressiveness in Neuroblastoma

28 Apr 2011

Abstract excerpt

MMSET (WHSC1/NSD2) is a SET domain-containing histone lysine methyltransferase the expression of which is deregulated in a subgroup of multiple myelomas with the t(4;14)(p16;q32) translocation associated with poor prognosis. Recent studies have shown that MMSET mRNA levels are increased in other tumor types as well. We have carried out immunohistochemical staining of tissue microarrays and found that MMSET...

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PMID: 21527557
DOI: 10.1158/0008-5472.can-10-3810

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