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Article

EZH2 regulates neuroblastoma cell differentiation via NTRK1 promoter epigenetic modifications

2 Mar 2018

Abstract excerpt

The polycomb repressor complex 2 molecule EZH2 is now known to play a role in essential cellular processes, namely, cell fate decisions, cell cycle regulation, senescence, cell differentiation, and cancer development/progression. EZH2 inhibitors have recently been developed; however, their effectiveness and underlying molecular mechanisms in many malignancies have not yet been elucidated in detail. Although the...

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PMID: 29507419
DOI: 10.1038/s41388-018-0133-3

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