Article
Altered expression of miRNAs and methylation of their promoters are correlated in neuroblastoma.
Oncotarget - 13 Dec 2016
Maugeri Marco, Barbagallo Davide, Barbagallo Cristina, Banelli Barbara, Di Mauro Stefania, Purrello Francesco, Magro Gaetano, Ragusa Marco, Di Pietro Cinzia, Romani Massimo, Purrello Michele
Abstract excerpt
Neuroblastoma is the most common human extracranial solid tumor during infancy. Involvement of several miRNAs in its pathogenesis has been ascertained. Interestingly, most of their encoding genes reside in hypermethylated genomic regions: thus, their tumor suppressor function is normally disallowed in these tumors. To date, the therapeutic role of the demethylating agent 5'-Aza-2 deoxycytidine (5'-AZA) and its...
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