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Characterization of unusual iAMP21 B‐lymphoblastic leukemia ( iAMP21‐ALL ) from the Mayo Clinic and Children's Oncology Group

30 Jun 2022

Abstract excerpt

Acute lymphoblastic leukemia (B-ALL) with intrachromosomal amplification of chromosome 21 (iAMP21-ALL) represents a recurrent high-risk cytogenetic abnormality and accurate identification is critical for appropriate clinical management. Identification of iAMP21-ALL has historically relied on fluorescence in situ hybridization (FISH) using a RUNX1 probe. Current classification requires ≥ five copies of RUNX1 per...

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PMID: 35771717
DOI: 10.1002/gcc.23084

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