Article
The association between single nucleotide polymorphisms of GSK 3β gene and sporadic Alzheimer's disease in a cohort of southern Chinese Han population.
Neurotoxicity research - 1 Nov 2014
Li Jing, Zeng Fan, Deng Juan, Zhu Jie, Li Lin, Zhang Tao, Liu Juan, Zhang Li-Li, Gao Chang-Yue, Zhang Meng, Xu Zhi-Qiang, Zhou Hua-Dong, Wang Yan-Jiang
Abstract excerpt
Recent studies suggest that genetic factors contribute to the pathogenesis of sporadic Alzheimer's disease (sAD). Glycogen synthase kinase-3 beta (GSK 3β) is an important molecule which regulates tau phosphorylation and neurofibrillary tangles formation. GSK 3β gene may be a potential candidate gene for the risk of sAD. To investigate the association of the polymorphisms in GSK 3β gene with sAD, we conducted a...
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