Article
Association of polymorphism in the promoter of the melatonin receptor 1A gene with schizophrenia and with insomnia symptoms in schizophrenia patients.
Journal of molecular neuroscience : MN - 1 Oct 2011
Park Hae Jeong, Park Jin Kyung, Kim Su Kang, Cho Ah-Rang, Kim Jong Woo, Yim Sung-Vin, Chung Joo-Ho
Abstract excerpt
Schizophrenia patients commonly have sleep disturbances. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in the promoter region of the melatonin receptor genes (MTNR1A and MTNR1B) were associated with schizophrenia and with sleep problems such as insomnia and hypersomnia in schizophrenia patients. We genotyped two promoter SNPs [rs2119882 (-184T/C) of MTNR1A and rs4753426 (-1193C/T)...
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