Article
Analysis of genetic variations in the human melatonin receptor (MTNR1A, MTNR1B) genes and antipsychotics-induced tardive dyskinesia in schizophrenia.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Mar 2011
Lai I-Ching, Chen Mao-Liang, Wang Ying-Chieh, Chen Jen-Yeu, Liao Ding-Lieh, Bai Ya-Mei, Lin Chao-Cheng, Chen Tzu-Ting, Liou Ying-Jay
Abstract excerpt
OBJECTIVES: Antipsychotics-induced tardive dyskinesia (TD) has been suggested to be related to altered dopaminergic neurotransmission in the striatum. Melatonin has a modulating effect on dopaminergic neurotransmission in the brain; therefore, the hypothesis of an association between the melatonin receptor genes (MTNR1A, MTNR1B) and antipsychotics-induced TD was examined in this study. METHODS: Schizophrenic...
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