Article
Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells.
Science translational medicine - 27 Apr 2011
Butler Marcus O, Friedlander Philip, Milstein Matthew I, Mooney Mary M, Metzler Genita, Murray Andrew P, Tanaka Makito, Berezovskaya Alla, Imataki Osamu, Drury Linda, Brennan Lisa, Flavin Marisa, Neuberg Donna, Stevenson Kristen, Lawrence Donald, Hodi F Stephen, Velazquez Elsa F, Jaklitsch Michael T, Russell Sara E, Mihm Martin, Nadler Lee M, Hirano Naoto
Abstract excerpt
Although advanced-stage melanoma patients have a median survival of less than a year, adoptive T cell therapy can induce durable clinical responses in some patients. Successful adoptive T cell therapy to treat cancer requires engraftment of antitumor T lymphocytes that not only retain specificity and function in vivo but also display an intrinsic capacity to survive. To date, adoptively transferred antitumor...
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