Article
Evidence of association with type 1 diabetes in the SLC11A1 gene region.
BMC medical genetics - 27 Apr 2011
Yang Jennie H M, Downes Kate, Howson Joanna M M, Nutland Sarah, Stevens Helen E, Walker Neil M, Todd John A
Abstract excerpt
BACKGROUND: Linkage and congenic strain analyses using the nonobese diabetic (NOD) mouse as a model for human type 1 autoimmune diabetes (T1D) have identified several NOD mouse Idd (insulin dependent diabetes) loci, including Slc11a1 (formerly known as Nramp1). Genetic variants in the orthologous region encompassing SLC11A1 in human chromosome 2q35 have been reported to be associated with various immune-related...
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