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Article

Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: a case control study.

BMC medical genetics - 23 Jun 2006

Santiago Jose Luis, Martínez Alfonso, de la Calle Hermenegildo, Fernández-Arquero Miguel, Figueredo M Angeles, de la Concha Emilio G, Urcelay Elena

Abstract excerpt

BACKGROUND: Type 1 diabetes (T1D) is a chronic, autoimmune and multifactorial disease characterized by abnormal metabolism of carbohydrate and fat. Diminished carnitine plasma levels have been previously reported in T1D patients and carnitine increases the sensitivity of the cells to insulin. Polymorphisms in the carnitine transporters, encoded by the SLC22A4 and SLC22A5 genes, have been involved in...

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PMID: 16796743
DOI: 10.1186/1471-2350-7-54
PMCID: PMC1513557

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