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Article

A novel functional TagSNP Rs7560488 in the DNMT3A1 promoter is associated with susceptibility to gastric cancer by modulating promoter activity.

PloS one - 1 Jan 2014

Wu Huazhang, Zhang Kun, Gong Pihai, Qiao Fengchang, Wang Ling, Cui He, Sui Xinyuan, Gao Jifan, Fan Hong

Abstract excerpt

DNA-methyltransferase (DNMT)-3A which contains DNMT3A1 and DNMT3A2 isoforms have been suggested to play a crucial role in carcinogenesis and showed aberrant expression in most cancers. Accumulated evidences also indicated that single nucleotide polymorphisms (SNP) in DNMT genes were associated with susceptibility to different tumors. We hypothesized that genetic variants in DNMT3A1 promoter region are associated...

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Source

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Identifiers

PMID: 24667323
DOI: 10.1371/journal.pone.0092911
PMCID: PMC3965498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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