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Article

On Robust Association Testing for Quantitative Traits and Rare Variants.

G3 (Bethesda, Md.) - 7 Dec 2016

Wei Peng, Cao Ying, Zhang Yiwei, Xu Zhiyuan, Kwak Il-Youp, Boerwinkle Eric, Pan Wei

Abstract excerpt

With the advance of sequencing technologies, it has become a routine practice to test for association between a quantitative trait and a set of rare variants (RVs). While a number of RV association tests have been proposed, there is a dearth of studies on the robustness of RV association testing for nonnormal distributed traits, e.g., due to skewness, which is ubiquitous in cohort studies. By extensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27678522
DOI: 10.1534/g3.116.035485
PMCID: PMC5144964

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