Article
Autoimmune human T lymphocytes specific for acetylcholine receptor.
Nature - 1 Jan 2000
Hohlfeld R, Toyka K V, Heininger K, Grosse-Wilde H, Kalies I
Abstract excerpt
Myasthenia gravis is one of the best characterized human autoimmune disorders. Circulating autoantibodies to the nicotinic acetylcholine receptor (AChR) at the neuromuscular junction play a prominent part in the effector phase, that is, the immunoregulation. Indirect evidence, such as thymic abnormalities and the association with certain histocompatibility antigens (for example HLA-B8,-DR3) suggests a defect of...
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