Article
Autoimmune human T lymphocytes specific for acetylcholine receptor.
Nature - 1 Jan 2000
Hohlfeld R, Toyka K V, Heininger K, Grosse-Wilde H, Kalies I
Abstract excerpt
Myasthenia gravis is one of the best characterized human autoimmune disorders. Circulating autoantibodies to the nicotinic acetylcholine receptor (AChR) at the neuromuscular junction play a prominent part in the effector phase, that is, the immunoregulation. Indirect evidence, such as thymic abno...
Topics
- Autoimmune Diseases
- Cell Line
- Cell Separation
- HLA-DR Antigens
- HLA-DR3 Antigen
- Histocompatibility Antigens Class II
- Humans
- Myasthenia Gravis
- Phenotype
- Receptors, Cholinergic
- T-Lymphocytes