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Article

Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia.

Blood - 15 Nov 1991

Semple J W, Freedman J

Abstract excerpt

Chronic autoimmune thrombocytopenic purpura (ATP) is a common hematologic disorder in which platelet-specific autoantibodies bind to platelets and enhance their destruction by the reticuloendothelial system. While there has been considerable investigation of the humoral immune abnormalities in ATP, little work has been performed on the cellular immunoregulatory aspects of this autoimmune disorder. We describe...

Topics

Adult
Antigens, CD
Blood Platelets
CD8 Antigens
Cells, Cultured
Complement System Proteins
Female
Humans
Interleukin-2
Kinetics
Lymphocyte Activation
Lymphocyte Subsets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Phenotype

Purpura, Thrombocytopenic, Idiopathic

Reference Values

T-Lymphocytes, Helper-Inducer

Source

Identifiers

PMID: 1840468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1840468-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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