Article
Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease.
Clinical and experimental immunology - 1 Dec 1994
Wu Z, Podack E R, McKenzie J M, Olsen K J, Zakarija M
Abstract excerpt
Infiltration of the thyroid gland by lymphocytes is a hall-mark of autoimmune thyroid disease; it is particularly evident in Hashimoto's thyroiditis but is also seen in most patients with Graves' disease. Infiltrating cells are comprised primarily of T lymphocytes, of which only a minority appears to be activated. Their precise pathogenic role is largely unknown. Since perforin has been a marker for functionally...
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