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Article

Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection.

Nature genetics - 1 May 2011

Ford Christopher B, Lin Philana Ling, Chase Michael R, Shah Rupal R, Iartchouk Oleg, Galagan James, Mohaideen Nilofar, Ioerger Thomas R, Sacchettini James C, Lipsitch Marc, Flynn JoAnne L, Fortune Sarah M

Abstract excerpt

Tuberculosis poses a global health emergency, which has been compounded by the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains. We used whole-genome sequencing to compare the accumulation of mutations in Mtb isolated from cynomolgus macaques with active, latent or reactivated disease. We sequenced 33 Mtb isolates from nine macaques with an average genome coverage of 93% and an average read...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21516081
DOI: 10.1038/ng.811
PMCID: PMC3101871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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