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Article

Whole genome sequencing of Mycobacterium tuberculosis reveals slow growth and low mutation rates during latent infections in humans.

PloS one - 1 Jan 2014

Colangeli Roberto, Arcus Vic L, Cursons Ray T, Ruthe Ali, Karalus Noel, Coley Kathy, Manning Shannon D, Kim Soyeon, Marchiano Emily, Alland David

Abstract excerpt

Very little is known about the growth and mutation rates of Mycobacterium tuberculosis during latent infection in humans. However, studies in rhesus macaques have suggested that latent infections have mutation rates that are higher than that observed during active tuberculosis disease. Elevated mutation rates are presumed risk factors for the development of drug resistance. Therefore, the investigation of...

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Identifiers

PMID: 24618815
DOI: 10.1371/journal.pone.0091024
PMCID: PMC3949705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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