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Article

Mycobacterium tuberculosis progresses through two phases of latent infection in humans.

Nature communications - 25 Sept 2020

Colangeli Roberto, Gupta Aditi, Vinhas Solange Alves, Chippada Venkata Uma Deepthi, Kim Soyeon, Grady Courtney, Jones-López Edward C, Soteropoulos Patricia, Palaci Moisés, Marques-Rodrigues Patrícia, Salgame Padmini, Ellner Jerrold J, Dietze Reynaldo, Alland David

Abstract excerpt

Little is known about the physiology of latent Mycobacterium tuberculosis infection. We studied the mutational rates of 24 index tuberculosis (TB) cases and their latently infected household contacts who developed active TB up to 5.25 years later, as an indication of bacterial physiological state and possible generation times during latent TB infection in humans. Here we report that the rate of new mutations in...

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Identifiers

PMID: 32978384
DOI: 10.1038/s41467-020-18699-9
PMCID: PMC7519141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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