Article
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.
Nature immunology - 1 May 2014
Mauer Jan, Chaurasia Bhagirath, Goldau Julia, Vogt Merly C, Ruud Johan, Nguyen Khoa D, Theurich Sebastian, Hausen A Christine, Schmitz Joel, Brönneke Hella S, Estevez Emma, Allen Tamara L, Mesaros Andrea, Partridge Linda, Febbraio Mark A, Chawla Ajay, Wunderlich F Thomas, Brüning Jens C
Abstract excerpt
Obesity and resistance to insulin are closely associated with the development of low-grade inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its role in this context remains controversial. Here we found that mice with an inactivated gene encoding the IL-6Rα chain of the receptor for IL-6 in myeloid cells (Il6ra(Δmyel) mice) developed exaggerated deterioration of glucose...
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