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Article

Structure and mutation analysis of archaeal geranylgeranyl reductase.

Journal of molecular biology - 17 Jun 2011

Sasaki Daisuke, Fujihashi Masahiro, Iwata Yuki, Murakami Motomichi, Yoshimura Tohru, Hemmi Hisashi, Miki Kunio

Abstract excerpt

The crystal structure of geranylgeranyl reductase (GGR) from Sulfolobus acidocaldarius was determined in order to elucidate the molecular mechanism of the catalytic reaction. The enzyme is a flavoprotein and is involved in saturation of the double bonds on the isoprenoid moiety of archaeal membranes. The structure determined in this study belongs to the p-hydroxybenzoate hydroxylase family in the glutathione...

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Identifiers

PMID: 21515284
DOI: 10.1016/j.jmb.2011.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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